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Flow Cytometry

Flow Cytometry

The development of flow cytometry techniques began in 1934 with initial attempts by Andrew Moldavan, a bacteriologist who counted the cells in a flowing capillary system. Moldavan pumped cells through a capillary tube focused under a microscope for visualization. The invention of photometry allowed the measurement of differentially-stained cells, and Louis Kamentsky developed the first multiparameter flow cytometer in 1965 to identify and count the cancer cells in cervical tissue specimens.
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Related Experiment Video

Updated: Jun 27, 2025

Cell Block Preparation from Cytology Specimen with Predominance of Individually Scattered Cells

Cell Block Preparation from Cytology Specimen with Predominance of Individually Scattered Cells

Published on: July 21, 2009

Optimal Volume Assessment for Serous Fluid Cytology.

Konstantinos Christofidis¹, Maria Theochari², Stylianos Mavropoulos Papoudas³

¹Cytopathology Laboratory, "Laiko" General Hospital of Athens, 11527 Athens, Greece.

|April 27, 2024

Summary

This summary is machine-generated.

Serous fluid volume does not impact diagnostic accuracy in serous effusion cytology. The International System for Reporting Serous Fluid Cytopathology (TIS) categories are not clinically affected by specimen volume, allowing for practical volume selection.

Keywords:

The International System for Reporting Serous Fluid Cytopathology (TIS)optimal volume serous effusion cytology

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Last Updated: Jun 27, 2025

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Published on: August 9, 2021

Area of Science:

Cytopathology
Oncology
Fluid analysis

Background:

Accurate diagnosis of serous effusions is crucial for patient management.
The International System for Reporting Serous Fluid Cytopathology (TIS) provides a standardized classification.
Understanding factors influencing diagnostic categories, such as fluid volume, is important.

Purpose of the Study:

To determine the optimal serous fluid volume for accurate diagnosis using TIS.
To analyze the distribution of serous effusion cases across TIS categories.
To correlate fluid volume with TIS categories and epidemiological data.

Main Methods:

Retrospective analysis of 2340 serous effusion cases (pleural, peritoneal, pericardial).
Assignment of TIS categories (ND, NFM, AUS, SFM, MAL) to each case.
Correlation of fluid volume with TIS categories in 1181 cases.

Main Results:

Statistically significant differences in fluid volume distributions were found between certain TIS categories.
Lower volumes were observed in Negative for Malignancy (NFM) compared to Malignant (MAL) cases.
Differences in volume were not clinically significant for diagnostic accuracy.

Conclusions:

Fluid volume has a minimal influence on TIS category assignment.
Fluid volume does not impact the diagnostic accuracy of serous effusion cytology.
Ideal serous effusion specimen volume should be based on practical considerations.