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Phosphatidylethanolamine Improves Postnatal Growth Retardation by Regulating Mucus Secretion of Intestinal Goblet

Nan Wang1,2, Chengming Wang1,2, Ming Qi1,2

  • 1College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.

Animals : an Open Access Journal From MDPI
|April 27, 2024
PubMed

Insights

Phosphatidylethanolamine (PE) supplementation improved growth in piglets with postnatal growth retardation (PGR). PE enhanced intestinal barrier function, increased MUC2 expression, and promoted goblet cell differentiation, alleviating PGR symptoms.

Area of Science:

  • Neonatal nutrition
  • Gastroenterology
  • Animal science

Background:

  • Phosphatidylethanolamine (PE) is a vital phospholipid for neonatal development.
  • Postnatal growth retardation (PGR) negatively impacts neonate growth and intestinal health.
  • Improving intestinal barrier function is a key strategy to address PGR.

Purpose of the Study:

  • To investigate the effects of exogenous Phosphatidylethanolamine (PE) on postnatal growth retardation (PGR) in neonatal pigs.
  • To determine if PE supplementation can improve intestinal barrier function in piglets with PGR.
  • To elucidate the mechanisms by which PE influences intestinal health and growth.

Main Methods:

  • Thirty-two neonatal pigs were divided into control and PE-supplemented groups, with normal birth weight (NBW) and PGR subgroups.
  • PE was administered during lactation and post-weaning periods.
  • Intestinal morphology, MUC2 expression, goblet cell differentiation (Spdef), and endoplasmic reticulum stress markers were analyzed.

Main Results:

  • PE supplementation improved growth performance in PGR piglets compared to controls.
  • PGR piglets exhibited damaged intestinal morphology, which PE partially restored by increasing villus height to crypt depth ratio and goblet cell numbers.
  • PE increased MUC2 expression and Spdef mRNA levels while reducing endoplasmic reticulum stress markers in PGR piglets.

Conclusions:

  • Exogenous Phosphatidylethanolamine (PE) effectively alleviates postnatal growth retardation (PGR) in neonatal pigs.
  • PE enhances intestinal barrier function by promoting goblet cell differentiation and MUC2 expression.
  • PE supplementation represents a promising strategy for improving neonatal growth and intestinal health.

Keywords:
endoplasmic reticulum stressintestinal barrierphosphatidylethanolaminepigletspostnatal growth retardation

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