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Updated: Jun 27, 2025

Identification of Circular RNAs using RNA Sequencing
08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

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Dysregulated Expression Patterns of Circular RNAs in Cancer: Uncovering Molecular Mechanisms and Biomarker Potential

Nicole R DeSouza1, Kate J Nielsen1, Tara Jarboe1

  • 1Department of Pathology, Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA.

Biomolecules
|April 27, 2024
PubMed

Insights

Circular RNAs (circRNAs) are novel non-coding RNA molecules. Their dysregulation drives cancer, offering potential as diagnostic biomarkers for early detection and personalized medicine.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • Circular RNAs (circRNAs) are non-coding RNA molecules formed by back-splicing.
  • They possess stable structures and regulatory functions.
  • Dysregulated circRNA expression is implicated in cancer development.

Purpose of the Study:

  • To review the novel roles of circRNAs in cancer.
  • To highlight their potential as diagnostic and prognostic biomarkers.
  • To explore their application in personalized medicine.

Main Methods:

  • Literature review of studies on circRNA biogenesis and function.
  • Analysis of circRNA involvement in epigenetic modifications and cancer pathways.
  • Evaluation of circRNA expression patterns for biomarker discovery.

Main Results:

  • CircRNAs exhibit dynamic regulatory capabilities via RNA and protein-binding domains.
  • Their dysregulation contributes to carcinogenic and tumorigenic processes.
  • Novel molecular and cellular patterns in cancer cells are identified through circRNA studies.

Conclusions:

  • CircRNAs are emerging as significant players in cancer biology.
  • Reliable circRNA expression patterns can facilitate early disease detection.
  • CircRNAs hold promise as genome-specific biomarkers for personalized cancer medicine.
Keywords:
cancercircRNAcircRNA applicationcircRNA functioncircular RNAs

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