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Transient Receptor Potential Canonical 5 (TRPC5): Regulation of Heart Rate and Protection against Pathological
Pratish Thakore1,2, James E Clark1, Aisah A Aubdool1
1BHF Cardiovascular Centre of Research Excellence, School of Cardiovascular and Metabolic Medicine & Sciences, King's College London, London SE1 9NH, UK.
Biomolecules
|April 27, 2024
Summary
Transient Receptor Potential Canonical 5 (TRPC5) channels regulate heart rate and protect against cardiac hypertrophy. TRPC5 knockout mice exhibit reduced heart rate and exaggerated hypertrophy in response to stress.
Area of Science:
- Cardiovascular Physiology
- Ion Channel Biology
- Cardiac Pathophysiology
Background:
- Transient Receptor Potential Canonical 5 (TRPC5) channels are present in cardiomyocytes, but their in vivo physiological and pathological roles remain unclear.
- Understanding TRPC5 function is crucial for elucidating cardiac regulation and disease mechanisms.
Purpose of the Study:
- To investigate the role of TRPC5 in cardiac function under basal conditions.
- To determine the involvement of TRPC5 in the development of cardiac hypertrophy.
Main Methods:
- Assessment of cardiovascular parameters in wild-type (WT) and global TRPC5 knockout (KO) mice.
- Echocardiography, drug-induced pressure changes, isolated heart studies, and abdominal aortic banding (AAB) model of cardiac hypertrophy.
Main Results:
- TRPC5 KO mice showed reduced heart rate, increased stroke volume, and enhanced parasympathetic control.
- TRPC5 KO mice exhibited an exaggerated hypertrophic response to AAB, with increased markers of hypertrophy, fibrosis, reactive oxygen species, and angiogenesis.
- TRPC5 channels influence basal cardiac pacing and autonomic regulation of heart rate.
Conclusions:
- TRPC5 plays a significant role in maintaining normal heart rate and parasympathetic regulation.
- TRPC5 acts as a protective factor against pathological cardiac hypertrophy.
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