A Matter of Margins in Oral Cancer-How Close Is Enough?
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Positive surgical margins significantly increase distant failure risk in oral cancer patients. A deep margin over 3 mm in close margin cases may offer survival comparable to clear margins.
Area Of Science
- Oncology
- Surgical Pathology
Background
- Risk factors for oral cancer recurrence based on surgical margin status are not well-defined.
- Understanding these factors is crucial for optimizing treatment and improving patient outcomes.
Purpose Of The Study
- To identify risk factors for oral cancer recurrence according to surgical margin status.
- To determine an optimal margin cut-off point for improved survival in patients with close margins.
Main Methods
- Retrospective review of 326 adult patients with primary oral cancer treated between 2009 and 2021.
- Classification of surgical margins as positive (<1 mm), close (1-4.9 mm), or clear (>5 mm).
- Univariate and multivariate analyses to assess recurrence risk factors.
Main Results
- Positive surgical margins were the strongest predictor of distant failure (HR = 7.53), particularly without nodal involvement.
- In the close margin group, a deep margin > 3 mm was associated with disease-free and overall survival comparable to the clear margin group.
- Approximately 51.5% of patients had close margins (1-4.9 mm).
Conclusions
- Surgical margin status is a critical factor in oral cancer recurrence.
- A deep margin of > 3 mm may be sufficient in select oral cancer cases, potentially redefining 'close' margins.
- Further prospective studies are needed to validate these findings and guide clinical practice.
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
