Jove
Visualize
Contact Us

Related Concept Videos

Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

8.8K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.8K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

7.4K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Thyroid differentiation profile for differentiated thyroid cancer.

Endocrine oncology (Bristol, England)·2025
Same author

Metabolic Consequences of Thyroidectomy and Patient-Centered Management.

Journal of clinical medicine·2024
Same author

Molecular Perspectives in Radioactive Iodine Theranostics: Current Redifferentiation Protocols for Mis-Differentiated Thyroid Cancer.

Journal of clinical medicine·2024
Same author

Molecular Profiling of 50 734 Bethesda III-VI Thyroid Nodules by ThyroSeq v3: Implications for Personalized Management.

The Journal of clinical endocrinology and metabolism·2023
Same author

Thyroidectomy without Radioiodine in Low-Risk Thyroid Cancer.

The New England journal of medicine·2022
Same author

Radiomicrosphere Dosimetry: Principles and Current State of the Art.

Seminars in nuclear medicine·2022
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 27, 2025

Comparative Lesions Analysis Through a Targeted Sequencing Approach
08:16

Comparative Lesions Analysis Through a Targeted Sequencing Approach

Published on: November 5, 2019

6.7K

Theranostic Risk Stratification for Thyroid Cancer in the Genomic Paradigm.

Seza A Gulec1,2, Evander Meneses1

  • 1Miami Cancer Research Center, Miami, FL 33181, USA.

Cancers
|April 27, 2024
PubMed
Summary

Theranostics guide personalized thyroid cancer treatment. Molecular profiling before surgery predicts response to radioactive iodine (RAI) therapy, improving patient outcomes.

Keywords:
differentiated thyroid cancergenomicsmis-differentiated thyroid cancermolecular theranosticsradioactive iodine indifferentradioactive iodine refractoryradioactive iodine theranosticsredifferentiationrisk stratificationtheranostics

More Related Videos

Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

1.6K
Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma
06:08

Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma

Published on: June 2, 2023

1.7K

Related Experiment Videos

Last Updated: Jun 27, 2025

Comparative Lesions Analysis Through a Targeted Sequencing Approach
08:16

Comparative Lesions Analysis Through a Targeted Sequencing Approach

Published on: November 5, 2019

6.7K
Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

1.6K
Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma
06:08

Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma

Published on: June 2, 2023

1.7K

Area of Science:

  • Oncology
  • Molecular Biology
  • Nuclear Medicine

Background:

  • Theranostics integrate diagnostics and therapeutics for patient-specific decisions.
  • Molecular theranostics in thyroid cancer involves multi-omic profiling for functional differentiation.
  • Functional differentiation impacts radioactive iodine (RAI) imaging accuracy and treatment efficacy.

Purpose of the Study:

  • To discuss the oncopathophysiologic basis of theranostic risk stratification in thyroid cancer.
  • To highlight the role of molecular profiling in predicting therapeutic response.
  • To emphasize the importance of functional differentiation in guiding RAI treatment.

Main Methods:

  • Review of current literature on molecular theranostics in thyroid cancer.
  • Discussion of genomic, transcriptomic, proteomic, metabolomic, and phenomic profiling.
  • Analysis of the relationship between molecular profiles and RAI treatment response.

Main Results:

  • Preoperative genomic and transcriptomic profiling are strong predictors of therapeutic intervention response.
  • Functional differentiation is key to successful RAI imaging and treatment.
  • Total thyroidectomy is often performed in anticipation of RAI treatment.

Conclusions:

  • Theranostic approaches, guided by molecular profiling, are crucial for optimizing thyroid cancer management.
  • Understanding functional differentiation enhances the effectiveness of RAI therapy.
  • Risk stratification based on theranostic principles improves patient-specific therapeutic strategies.