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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. The Influence Of Tumor-specific Markers In Breast Cancer On Other Blood Parameters.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. The Influence Of Tumor-specific Markers In Breast Cancer On Other Blood Parameters.

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The Influence of Tumor-Specific Markers in Breast Cancer on Other Blood Parameters.

Vlad Bogdan Varzaru1,2, Anca-Elena Eftenoiu3, Daliborca Cristina Vlad4,5

  • 1Doctoral School, Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania.

Life (Basel, Switzerland)
|April 27, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

This study found no significant correlation between breast cancer marker CA 15-3 and other common blood tests like CA125, CEA, AFP, or thyroid/parathyroid hormones. These findings suggest limited utility for these markers in predicting breast cancer status.

Keywords:
blood test parametersbreast cancertumor markerswomen

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Area of Science:

  • Oncology
  • Clinical Chemistry
  • Biomarker Research

Background:

  • Breast cancer is a leading cause of cancer-related deaths in women globally.
  • Limited data exists on serum tumor markers in breast cancer and their correlation with other blood parameters.
  • Understanding these correlations is crucial for improving clinical management.

Purpose of the Study:

  • To evaluate the correlation between breast cancer tumor-specific markers and other blood parameters.
  • To assess the potential impact of these correlations on clinical management strategies.

Main Methods:

  • Retrospective data analysis from January 2020 to May 2023 at County Hospital of Timisoara, Romania.
  • Inclusion of cases where serum tumor-specific biomarkers for breast cancer were analyzed.
  • Statistical analysis to identify relationships between CA 15-3 and other biomarkers/blood parameters.

    • Main Results:

    • No statistically significant associations were found between CA 15-3 and CA125, CEA, AFP, fT4, TSH, or PTH.
    • Statistical tests (chi-squared, Fisher's exact) confirmed the lack of correlation (p > 0.05 for all).

    Conclusions:

    • The study indicates a lack of strong correlation between CA 15-3 and common biomarkers including CA125, CEA, AFP, thyroid function tests, and PTH.
    • These findings suggest that CA 15-3 may not be a reliable indicator when correlated with these specific parameters in breast cancer patients.