Related Experiment Video

Updated: Jun 27, 2025

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus
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Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus

Published on: March 6, 2019

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Association of Fetal Lung Development Disorders with Adult Diseases: A Comprehensive Review

Alexey V Yaremenko1,2, Nadezhda A Pechnikova3,4, Konstantinos Porpodis2

  • 1Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Journal of Personalized Medicine
|April 27, 2024
PubMed

Insights

Disruptions in fetal lung development are linked to adult respiratory diseases like asthma and COPD. Understanding these connections aids in early prevention and better long-term respiratory health.

Area of Science:

  • Developmental Biology
  • Respiratory Medicine
  • Public Health

Background:

  • Fetal lung development is critical for lifelong respiratory health.
  • Disorders during this period can lead to neonatal complications and adult disease.
  • The developmental origins of adult diseases are increasingly recognized.

Purpose of the Study:

  • To comprehensively review the association between fetal lung development disorders and adult diseases.
  • To explore the mechanisms linking these conditions.
  • To inform preventive strategies and clinical interventions.

Main Methods:

  • Literature review of fetal lung development stages and maturation factors.
  • Investigation of specific fetal lung disorders (RDS, BPD, CDH).
  • Analysis of epidemiological and clinical data on adult respiratory disease links.

Main Results:

  • Fetal lung disorders are associated with increased risk of adult asthma and COPD.
  • Epigenetic, transgenerational, and intrauterine factors may mediate these links.
  • Evidence highlights the long-term impact of early lung development disruptions.

Conclusions:

  • Early detection and management of fetal lung disorders are crucial for preventing adult respiratory diseases.
  • Further research into underlying mechanisms can optimize preventive strategies.
  • This review underscores the importance of addressing fetal lung health for lifelong well-being.

Keywords:
adult respiratory diseasesepigenetic modificationsfetal respiratory diseaseslung developmentneonatal outcomespreventive interventionstransgenerational effects

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