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Optic Nerve Neuroprotection in Glaucoma: A Narrative Review
Angela D'Angelo1, Livio Vitiello2, Filippo Lixi3
1Department of Medicine and Surgery, University of Naples "Federico II", 80138 Naples, NA, Italy.
Journal of Clinical Medicine
|April 27, 2024
Summary
Neuroprotective therapies, including nicotinamide and citicoline, show promise for managing glaucoma, an optic nerve disease. These natural compounds offer therapeutic benefits by shielding brain cells from damage.
Area of Science:
- Ophthalmology
- Neuroscience
- Pharmacology
Background:
- Glaucoma is a leading cause of irreversible blindness, characterized by optic nerve damage and vision loss.
- Current glaucoma treatments do not halt disease progression, necessitating novel therapeutic strategies.
- Neuroprotection is a key focus for managing neurodegenerative disorders, including ocular conditions like glaucoma.
Purpose of the Study:
- To review naturally derived compounds used for neuroprotection in glaucoma patients.
- To analyze the scientific evidence supporting the therapeutic and neuroprotective benefits of these compounds.
- To emphasize the mechanisms of action for compounds like nicotinamide and citicoline in glaucoma management.
Main Methods:
- Literature review of scientific data on naturally derived compounds.
- Analysis of clinical studies investigating neuroprotection in glaucoma.
- Focus on compounds currently used in clinical practice.
Main Results:
- Nicotinamide and citicoline are natural compounds with demonstrated neuroprotective properties.
- These compounds offer therapeutic benefits by protecting retinal ganglion cells and optic nerve head.
- Evidence supports their role in managing glaucoma progression.
Conclusions:
- Naturally derived compounds like nicotinamide and citicoline are valuable in glaucoma neuroprotection.
- Further research into these agents can optimize glaucoma treatment strategies.
- Exploiting neuroprotective properties of natural compounds represents a significant advancement in ophthalmology.
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