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The effect cystamine on gastric secretion in the rat
Agents and Actions
|August 1, 1979
Summary
Cystamine affects gastric secretion differently in conscious and anesthetized rats. It inhibits acid but boosts pepsin in conscious rats, while stimulating acid in anesthetized rats, suggesting complex mechanisms.
Area of Science:
- Pharmacology
- Gastroenterology
- Physiology
Background:
- Gastric secretion is regulated by complex mechanisms.
- Cystamine's role in gastric physiology is not fully understood.
Purpose of the Study:
- To investigate the effects of cystamine on gastric acid and pepsin secretion.
- To explore the mechanisms underlying cystamine's actions in different physiological states.
Main Methods:
- Studies were conducted in conscious gastric fistula rats and anesthetized rats.
- Pharmacological agents like atropine, metiamide, and cimetidine were used.
- Mast cell histamine depletion was induced using compound 48/80.
Main Results:
- In conscious rats, cystamine inhibited basal acid output but increased pepsin output, an effect blocked by atropine and metiamide.
- In anesthetized rats, cystamine stimulated gastric acid output, an effect blocked by cimetidine.
- Mast cell histamine depletion abolished the secretory response to cystamine.
Conclusions:
- Cystamine exhibits dual effects on gastric secretion depending on the preparation.
- Its actions involve histamine release and interactions with muscarinic and histamine receptors.