Bioactive Compounds Formulated in Phytosomes Administered as Complementary Therapy for Metabolic Disorders
Laura Toma1, Mariana Deleanu1, Gabriela Maria Sanda1
1Institute of Cellular Biology and Pathology "Nicolae Simionescu" of the Romanian Academy, 8 B.P. Haşdeu Street, 050568 Bucharest, Romania.
International Journal of Molecular Sciences
|April 27, 2024
Summary
Phytosome formulations enhance the therapeutic benefits of bioactive compounds for metabolic disorders by improving bioavailability and solubility. This innovative delivery system offers a promising complementary therapy for managing these widespread health conditions.
Area of Science:
- Pharmacology
- Biochemistry
- Drug Delivery Systems
Background:
- Metabolic disorders (MDs) like dyslipidemia, NAFLD, diabetes, obesity, and cardiovascular diseases pose significant health risks.
- Bioactive compounds (polyphenols, flavonoids, alkaloids, triterpenes) show therapeutic potential but suffer from low oral bioavailability, poor solubility, and rapid metabolism.
- These limitations hinder the efficacy of natural compounds in treating MDs.
Purpose of the Study:
- To review scientific evidence on the enhanced therapeutic benefits of phytosome-formulated bioactive compounds compared to free compounds.
- To explore the preparation, characterization, and bioavailability of phytosomes.
- To highlight commercially available phytosomes for alleviating MDs.
Main Methods:
- Literature review of scientific evidence on phytosome technology and its application in metabolic disorders.
- Analysis of studies comparing phytosome formulations with free bioactive compounds.
- Compilation of data on phytosome preparation, characterization, and bioavailability.
Main Results:
- Phytosome formulation significantly enhances the bioavailability and therapeutic efficacy of various bioactive compounds.
- Improved solubility and stability of compounds within phytosomes facilitate better absorption and cellular penetration.
- Evidence supports the use of phytosomes in ameliorating risk factors and treating established MDs.
Conclusions:
- Phytosomes represent an innovative and effective drug delivery system for bioactive compounds targeting metabolic disorders.
- This formulation strategy overcomes the limitations of conventional delivery, offering improved therapeutic outcomes.
- Phytosomes show potential as a complementary therapy to conventional treatments for MDs, improving patient health and quality of life.
Keywords:
bioactive compoundscardiovascular diseasesdiabetes mellitusdyslipidemiahepatic disordersinflammatory stressmetabolic disordersmetabolic syndromeoxidative stressphytosomesMore Related Videos
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