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Related Concept Videos

Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

86
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
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Serum Laboratory Studies, Stool Test, Breath Test01:30

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Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
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Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

141
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
141

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Exploring Potential Biomarkers in Oesophageal Cancer: A Comprehensive Analysis.

Adrianna Romanowicz1, Marta Lukaszewicz-Zajac1, Barbara Mroczko1,2

  • 1Department of Biochemical Diagnostics, Medical University of Bialystok, ul. Waszyngtona 15a, 15-269 Bialystok, Poland.

International Journal of Molecular Sciences
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Summary

New biomarkers like CXCL12 and IL-6 show promise for diagnosing esophageal cancer (OC) and predicting patient survival. These markers correlate with tumor stage and metastases, offering hope for earlier detection and better outcomes.

Keywords:
biomarkerclaudinscytokinesmetalloproteinasesoesophageal cancer

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Area of Science:

  • Oncology
  • Biomarker Discovery
  • Molecular Diagnostics

Background:

  • Esophageal cancer (OC) is a leading cause of cancer death, often diagnosed late, leading to poor survival.
  • There is a critical need for non-invasive, low-cost biomarkers to improve OC diagnosis and patient management.

Purpose of the Study:

  • To review and summarize original studies on the potential significance of various biomarkers in esophageal cancer.
  • To evaluate the correlation of these biomarkers with tumor stage, metastasis, and patient prognosis.

Main Methods:

  • Review of original studies on chemokines, receptors, inflammatory proteins, growth factors, claudins, MMPs, TIMPs, ADAMs, and nucleic acid-based biomarkers in OC.
  • Analysis of correlations between biomarker levels and clinicopathological parameters.
  • Assessment of prognostic value and diagnostic utility (AUC) of selected biomarkers.

Main Results:

  • Significant correlations were found between CXCL12, CXCR4, CXCL8/CXCR2, M-CSF, MMP-2, MMP-9, ADAM17, ADAMTS-6, and CLDN7 levels and OC tumor stage/metastasis.
  • CXCL12, CXCL8/CXCR2, IL-6, TIMP-2, ADAM9, and ADAMTS-6 are prognostic factors for OC patient survival.
  • IL-6, CXCR4, CXCL8, and MMP-9 show higher diagnostic utility than existing OC markers; CLDN18.2 is a target for novel therapies.

Conclusions:

  • Selected biomarkers, including chemokines, inflammatory proteins, and MMPs, are significantly associated with OC progression and prognosis.
  • These biomarkers offer potential for improved non-invasive diagnosis and risk stratification in esophageal cancer.
  • CLDN18.2 presents a potential target for future therapeutic strategies in OC treatment.