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Novel Fe3O4 Nanoparticles with Bioactive Glass-Naproxen Coating: Synthesis, Characterization, and In Vitro Evaluation
Thalita Marcolan Valverde1, Viviane Martins Rebello Dos Santos2, Pedro Igor Macário Viana1
1Departamento de Morfologia, Instituto de Ciências Biológicas (ICB), Universidade Federal de Minas Gerais (UFMG), Belo Horizonte 31270-901, MG, Brazil.
International Journal of Molecular Sciences
|April 27, 2024
Summary
New magnetic nanoparticles coated with bioactive glass and naproxen show promise for biomedical uses. These materials reduce inflammation and support bone cell growth, offering potential for improved implant applications.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Immunology
Background:
- Biomaterial surface properties influence immune responses, potentially causing chronic inflammation and implant failure.
- Developing advanced biomaterials is crucial for successful biomedical applications.
Purpose of the Study:
- To create multifunctional magnetic nanoparticles (MNPs) with silica and bioactive glass (BG) coatings.
- To incorporate the anti-inflammatory drug naproxen for enhanced therapeutic effects.
- To evaluate the MNPs' bioactivity, biocompatibility, and anti-inflammatory potential.
Main Methods:
- Synthesis and characterization of silica-coated magnetic nanoparticles with a bioactive glass layer.
- In vitro assessment of bioactivity using simulated body fluid (SBF) immersion.
- Evaluation of biocompatibility with bone cells, assessing viability and alkaline phosphatase (ALP) activity.
- Measurement of nitric oxide (NO) production as an inflammatory marker.
Main Results:
- Characterization confirmed magnetite core and silica-rich bioactive glass (BG) layer formation.
- In vitro studies showed apatite layer formation in SBF, indicating bioactivity.
- Nanoparticles demonstrated biocompatibility with bone cells, supporting viability and ALP activity.
- Naproxen (free or encapsulated) significantly reduced nitric oxide production, indicating anti-inflammatory effects.
Conclusions:
- The developed magnetic nanoparticles coated with BG and naproxen exhibit promising multifunctional properties.
- These nanoparticles demonstrate biocompatibility, bioactivity, and osteogenic potential.
- The combination of BG coating and naproxen provides significant anti-inflammatory activity, particularly in macrophages and for bone-related applications.
