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Ligand Binding and Linkage00:49

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Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence...
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Aptamers: Functional-Structural Studies and Biomedical Applications 2.0.

Romualdo Troisi1,2, Filomena Sica1

  • 1Department of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.

International Journal of Molecular Sciences
|April 27, 2024
PubMed
Summary
This summary is machine-generated.

This special issue explores aptamer technology, focusing on novel aptamer development and their diverse biomedical applications. Discover cutting-edge research in aptamer-based diagnostics and therapeutics.

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Area of Science:

  • Biochemistry and Molecular Biology
  • Biomedical Engineering
  • Drug Discovery and Development

Background:

  • This special issue builds upon previous work on aptamers, highlighting advancements in their functional and structural characterization.
  • It addresses the growing interest in aptamers as versatile tools for biomedical applications.

Discussion:

  • Explores the integration of aptamer technology with other scientific fields.
  • Discusses challenges and opportunities in aptamer-based diagnostics and therapeutics.

Key Insights:

  • Presents novel aptamer designs with enhanced stability and specificity.
  • Showcases innovative aptamer applications in disease detection and treatment.
  • Highlights the potential of aptamers in personalized medicine.

Outlook:

  • Foresees expanded clinical translation of aptamer-based therapies.
  • Predicts advancements in high-throughput aptamer screening and engineering.
  • Anticipates the development of next-generation aptamer-based biosensors.