Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

8.8K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.8K
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

4.1K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.1K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

7.4K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Potential Association of BRAF and PIK3CA Copy Number Alterations with Long-Term Survival in IDH-Wildtype Glioblastoma: A Pilot Study.

International journal of molecular sciences·2026
Same author

Comparison of protein-based and genetic prognostic markers in a large cohort of primary pulmonary and extrapulmonary small cell neuroendocrine carcinoma.

Lung cancer (Amsterdam, Netherlands)·2026
Same author

Volumetric regression of meningiomas following SRS and hFSRT - insights from long-term analysis.

Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology·2026
Same author

Altered DNA Methyltransferase Expression in Pulmonary Large-Cell Neuroendocrine Carcinoma: Pilot Experimental Data Targeted DNMT1, DNMT3A, and DNMT3B.

Cancer reports (Hoboken, N.J.)·2026
Same author

Evaluation of DICER1 Immunohistochemistry as a Potential Surrogate for Mutation Status in Ovarian Sex Cord-Stromal Tumors.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc·2026
Same author

Unusual immunohistochemical profiles in hemangioblastomas and their relevance in differential diagnosis: A comprehensive study of 112 cases.

Journal of neuropathology and experimental neurology·2026

Related Experiment Video

Updated: Jun 27, 2025

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures
06:32

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures

Published on: January 9, 2019

7.9K

Potential Diagnostic and Clinical Significance of Selected Genetic Alterations in Glioblastoma.

Silvia Tomoszková1,2, Jozef Škarda2,3, Radim Lipina1,2

  • 1Neurosurgery Clinic, University Hospital Ostrava, 17. listopadu 1790/5, 708 00 Ostrava, Czech Republic.

International Journal of Molecular Sciences
|April 27, 2024
PubMed
Summary
This summary is machine-generated.

Glioblastoma (GBM) survival depends on molecular properties. Identifying gene mutations and their effects on prognosis is key for future glioblastoma treatment strategies.

Keywords:
gene mutationsglioblastomaoverall survivalprognosis

More Related Videos

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
12:52

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Published on: November 28, 2015

15.8K
Modeling Astrocytoma Pathogenesis In Vitro and In Vivo Using Cortical Astrocytes or Neural Stem Cells from Conditional, Genetically Engineered Mice
10:13

Modeling Astrocytoma Pathogenesis In Vitro and In Vivo Using Cortical Astrocytes or Neural Stem Cells from Conditional, Genetically Engineered Mice

Published on: August 12, 2014

13.4K

Related Experiment Videos

Last Updated: Jun 27, 2025

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures
06:32

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures

Published on: January 9, 2019

7.9K
Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
12:52

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Published on: November 28, 2015

15.8K
Modeling Astrocytoma Pathogenesis In Vitro and In Vivo Using Cortical Astrocytes or Neural Stem Cells from Conditional, Genetically Engineered Mice
10:13

Modeling Astrocytoma Pathogenesis In Vitro and In Vivo Using Cortical Astrocytes or Neural Stem Cells from Conditional, Genetically Engineered Mice

Published on: August 12, 2014

13.4K

Area of Science:

  • Neuro-oncology
  • Molecular Biology
  • Genetics

Background:

  • Glioblastoma (GBM) is the most aggressive primary brain tumor, associated with high mortality.
  • Patient survival is typically 14 months, with only 2% surviving 3 years post-surgery.
  • Tumor molecular characteristics significantly influence glioblastoma patient outcomes.

Purpose of the Study:

  • To investigate gene mutations implicated in glioblastoma pathophysiology.
  • To understand how specific mutations affect patient prognosis and survival quality.
  • To explore the potential of molecular insights for therapeutic advancements in GBM.

Main Methods:

  • Systematic review of 71 retrospective studies published between 2016 and 2022.
  • Literature search conducted on PubMed.
  • Analysis focused on gene mutations within the context of glioblastoma (GBM).

Main Results:

  • Identified various mutations within specific gene groups affecting glioblastoma prognosis.
  • Observed that different mutations within the same gene can lead to varied survival outcomes.
  • Highlighted the role of associated gene mutations and intratumoral heterogeneity.

Conclusions:

  • Glioblastoma prognosis is intricately linked to a complex interplay of gene mutations.
  • Further research into these mutations and intratumoral heterogeneity is crucial.
  • Molecular profiling holds significant potential for improving glioblastoma patient care and treatment.