Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Parkinson's Disease: Overview

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...

Neural Regulation

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.

Alzheimer's Disease: Overview

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Value of Oral Health Assessments for Older People with Memory Complaints Visiting a Memory Clinic for a Comprehensive Geriatric Assessment: A Cross-Sectional Study.

International journal of environmental research and public health·2026

Same author

Barriers and Facilitators Concerning Involuntary Oral Care for Individuals with Dementia: A Qualitative Study.

International journal of environmental research and public health·2025

Same author

The Impact of Paratracheal Lymphadenectomy on Survival After Esophagectomy: A Nationwide Propensity Score Matched Analysis.

Cancers·2025

Same author

Development of Zinc-Containing Chitosan/Gelatin Coatings with Immunomodulatory Effect for Soft Tissue Sealing around Dental Implants.

Tissue engineering and regenerative medicine·2024

Same author

Necessity and influencing factors for integrating oral health in cancer care for older people: a narrative review.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2024

Same author

Biofunctionalization of dental abutments by a zinc/chitosan/gelatin coating to optimize fibroblast behavior and antibacterial properties.

Journal of biomedical materials research. Part A·2024

Search research articles

Related Experiment Video

Updated: Jun 27, 2025

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

Periodontitis: A Plausible Modifiable Risk Factor for Neurodegenerative Diseases? A Comprehensive Review.

Adelina S Plachokova¹, Jolijn Gjaltema¹, Eliza R C Hagens¹

¹Department of Dentistry, Radboud University Medical Center, 6525 EX Nijmegen, The Netherlands.

International Journal of Molecular Sciences

|April 27, 2024

Summary

Periodontitis is linked to Alzheimer's disease, with a potential two-way relationship. More research is needed to understand the connection between gum disease and neurodegenerative conditions like Parkinson's disease.

Keywords:

Alzheimer’s disease Parkinson’s disease neurodegenerative diseases neuroinflammation periodontitis risk factor

More Related Videos

Murine Model of Advanced Periodontitis Induced by Nylon Ligature in the Second Upper Molar

Murine Model of Advanced Periodontitis Induced by Nylon Ligature in the Second Upper Molar

Published on: May 30, 2025

Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model

Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model

Published on: February 17, 2023

Related Experiment Videos

Last Updated: Jun 27, 2025

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

Murine Model of Advanced Periodontitis Induced by Nylon Ligature in the Second Upper Molar

Murine Model of Advanced Periodontitis Induced by Nylon Ligature in the Second Upper Molar

Published on: May 30, 2025

Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model

Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model

Published on: February 17, 2023

Area of Science:

Oral Health and Neurology
Neuroinflammation Research

Background:

Periodontitis, a chronic inflammatory gum disease, shares risk factors with neurodegenerative diseases.
Emerging evidence suggests a potential link between oral health and brain health.

Purpose of the Study:

To review literature on periodontitis and neurodegenerative diseases.
To explore the bidirectional relationship and pathogenesis.
To identify common risk factors.

Main Methods:

Systematic review and meta-analysis of PubMed, Medline, and EMBASE.
Inclusion of 6 selected articles and additional relevant papers.
Analysis of mechanistic pathways and risk factors.

Main Results:

A significant association found between periodontitis and Alzheimer's disease (OR 3-5).
Weak evidence for periodontitis and Parkinson's disease, but correlation with poor oral health noted.
Humoral, neuronal, and cellular pathways involving periodontal pathogens like *Porphyromonas gingivalis* are hypothesized.

Conclusions:

Periodontal inflammation may contribute to neuroinflammation, linking periodontitis to neurodegeneration.
Common risk factors like age, genetics, and lifestyle influence both conditions.
Interdisciplinary collaboration between dentists and neurologists is crucial for future research.