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Lipid-Derived Biomarkers as Therapeutic Targets for Chronic Coronary Syndrome and Ischemic Stroke: An Updated
Thomas Gabriel Schreiner1,2,3, Bogdan Emilian Ignat1,4, Cristina Grosu1,4
1Department of Medical Specialties III, Faculty of Medicine, University of Medicine and Pharmacy "Grigore T. Popa", 700115 Iasi, Romania.
Medicina (Kaunas, Lithuania)
|April 27, 2024
Summary
This review explores how lipid biomarkers, like cholesterol and oxylipins, are crucial in understanding and treating heart (chronic coronary syndrome) and brain (ischemic stroke) conditions. Early detection and targeted therapies using these markers can improve patient outcomes.
Area of Science:
- Cardiovascular Medicine
- Neurology
- Biomarker Research
Background:
- Rising global incidence of cardiac and cerebrovascular diseases, particularly chronic coronary syndrome and ischemic stroke.
- The heart-brain axis involves shared pathophysiological mechanisms in cardiac and cerebral ischemia.
- Need for personalized medical treatments focusing on prevention and early intervention of risk factors.
Purpose of the Study:
- To provide an updated overview of lipid-derived biomarkers in chronic coronary syndrome and ischemic stroke.
- To elucidate the role of biomarkers like low-density lipoprotein cholesterol, oxylipins, and apolipoproteins in disease pathogenesis.
- To present current and experimental targeted therapies based on these lipid biomarkers.
Main Methods:
- Narrative review of epidemiological data.
- Analysis of the role of various lipid-derived biomarkers in the pathogenesis of chronic coronary syndrome and ischemic stroke.
- Review of existing and emerging therapeutic strategies targeting lipid biomarkers.
Main Results:
- Significant epidemiological burden of chronic coronary syndrome and ischemic stroke highlighted.
- Detailed listing of key lipid-derived biomarkers and their involvement in disease development.
- Presentation of targeted therapies, both current and experimental, linked to these biomarkers.
Conclusions:
- Lipid-derived biomarkers play a critical role in the pathophysiology of chronic coronary syndrome and ischemic stroke.
- Understanding these biomarkers is essential for developing targeted and personalized treatment strategies.
- This review offers novel insights into therapeutic interventions for these prevalent cardiovascular and cerebrovascular conditions.
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