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Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
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Related Experiment Video

Updated: Jun 22, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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Headache in Multiple Sclerosis: A Narrative Review.

Bożena Adamczyk1, Natalia Morawiec1, Sylwia Boczek1

  • 1Department of Neurology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, ul. 3 Maja 13-15, 41-800 Zabrze, Poland.

Medicina (Kaunas, Lithuania)
|April 27, 2024
PubMed
Summary

Headache is a common early symptom in multiple sclerosis (MS), affecting over half of patients. Certain MS treatments can also trigger headaches, impacting patient management.

Keywords:
headachemigrainemultiple sclerosisprodromal syndrometension-type headache

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Area of Science:

  • Neurology
  • Immunology
  • Neuroinflammation

Background:

  • Multiple sclerosis (MS) is a chronic central nervous system inflammatory disease.
  • It involves autoimmune damage to myelin and oligodendrocytes.
  • MS symptoms evolve over time, with a prodromal phase preceding diagnosis.

Purpose of the Study:

  • To review the relationship between headache and MS.
  • To offer clinical insights for patient management and treatment decisions.

Main Methods:

  • Literature review of studies on headache and MS.

Main Results:

  • Headache, particularly migraine and tension-type, affects 50-60% of MS patients.
  • Headache shows a female predilection (2-3:1 ratio).
  • Disease-modifying therapies like teriflunomide, interferons, ponesimod, alemtuzumab, and cladribine are linked to increased headache incidence.

Conclusions:

  • Headache is a significant early indicator in MS.
  • Understanding this link aids clinicians in diagnosis and treatment.
  • Optimized patient care requires considering headache in MS management.