Related Experiment Video

Updated: Jun 26, 2026

Novel Diagnostics in Revision Arthroplasty: Implant Sonication and Multiplex Polymerase Chain Reaction
10:35

Novel Diagnostics in Revision Arthroplasty: Implant Sonication and Multiplex Polymerase Chain Reaction

Published on: December 3, 2017

11.2K

Surgical Management of Periprosthetic Joint Infections in Hip and Knee Megaprostheses

Christoph Theil1, Sebastian Bockholt1, Georg Gosheger1

  • 1Department of Orthopedics and Tumor Orthopedics, Muenster University Hospital, Albert-Schweitzer-Campus 1, 48149 Muenster, Germany.

Medicina (Kaunas, Lithuania)
|April 27, 2024
PubMed

Insights

Managing periprosthetic joint infection after knee or hip megaprosthesis requires careful consideration of various surgical options. This review discusses debridement, implant retention or exchange, and ablative procedures for infection control.

Area of Science:

  • Orthopedic Surgery
  • Infectious Diseases
  • Oncology

Background:

  • Periprosthetic joint infection (PJI) is a serious complication following megaprosthetic reconstruction of bone defects involving the knee or hip.
  • Optimal management strategies for PJI after megaprosthesis are debated due to the rarity of these procedures.

Purpose of the Study:

  • To review and discuss current management options for PJI after megaprosthetic reconstruction.
  • To focus on recent literature (last 15 years) and data from specialized centers.

Main Methods:

  • Non-systematic review of existing literature.
  • Analysis of studies focusing on debridement, antibiotics, irrigation and retention (DAIR) with modular component exchange, single-stage implant exchange, two-stage exchanges, and ablative procedures.

Main Results:

  • Discusses indications, surgical details, and infection control outcomes for each management strategy.
  • Highlights the increasing relevance of PJI management due to the rise in revision arthroplasty and orthopedic oncology procedures.

Conclusions:

  • Effective management of PJI after megaprosthesis involves a range of surgical interventions.
  • Further research and data from dedicated centers are crucial for refining treatment protocols.
Keywords:
hip arthroplastyknee arthroplastymegaprosthesesmegaprosthesismetastasesrevision arthroplastysarcoma

More Related Videos

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials06:18

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials

Published on: March 3, 2023

1.4K
Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections04:37

Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections

Published on: February 2, 2024

784

Related Concept Videos

Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
Endocarditis III: Medical Management01:18

Endocarditis III: Medical Management

Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
Urinary Tract Calculi VI: Surgical Management01:25

Urinary Tract Calculi VI: Surgical Management

Procedures for Kidney StonesMedical intervention is necessary when kidney stones or renal calculi are too large to pass spontaneously (typically greater than 5 millimeters) when stones are accompanied by symptomatic infection (such as fever or pyelonephritis), when they impair kidney function, or when they cause persistent symptoms like severe pain, nausea, or urinary retention. Additionally, patients with only one kidney or those who cannot be treated with medical management also require...