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G-Protein Signaling Modulator 2 as a Potential Biomarker in Colorectal Cancer: Integrative Analysis Using Genetic

Doaa Jawad Kadhim1, Hanieh Azari1, Saeideh Khorshid Sokhangouy2

  • 1Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad 91779-48564, Iran.

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|April 27, 2024
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Summary

G-protein signaling modulator 2 (GPSM2) is upregulated in gastrointestinal cancers, including colorectal cancer (CRC). Elevated GPSM2 expression correlates with poor prognosis and immune evasion, suggesting its potential as a biomarker.

Keywords:
GPSM2TCGAcolorectal cancerpan-cancer

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Area of Science:

  • Oncology
  • Molecular Biology
  • Bioinformatics

Background:

  • Colorectal cancer (CRC) presents a global health challenge, necessitating novel biomarkers for improved diagnostics and therapeutics.
  • The G-protein signaling modulator (GPSM) family's role in cancer remains incompletely understood, particularly GPSM2 in gastrointestinal (GI) malignancies.

Purpose of the Study:

  • To conduct a comprehensive pan-cancer analysis of the GPSM2 gene in GI cancers.
  • To investigate GPSM2 expression, protein interactions, functional roles, prognostic value, genetic alterations, and immune infiltration associations.

Main Methods:

  • Bioinformatic analysis of publicly available datasets.
  • Investigation of GPSM2 expression patterns, protein-protein interactions, and functional enrichment.
  • Prognostic assessment, analysis of genetic alterations, and correlation with immune cell infiltration.

Main Results:

  • Consistent upregulation of GPSM2 expression observed across all analyzed GI cancer datasets.
  • GPSM2 is implicated in critical pathways involved in tumor progression.
  • Elevated GPSM2 expression is linked to poorer overall and disease-free survival.
  • GPSM2 exhibits genetic alterations and correlates with immune cell infiltration, suggesting a role in immune evasion.

Conclusions:

  • GPSM2 is a promising pan-GI cancer biomarker, particularly for colorectal cancer (CRC).
  • Its upregulation, prognostic implications, and association with immune evasion highlight its potential for therapeutic targeting.
  • Further research is needed to confirm its clinical utility in CRC management.