Gut Microbiome-How Does Two-Month Consumption of Fiber-Enriched Rolls Change Microbiome in Patients Suffering from...

Area of Science:

• Gastroenterology
• Microbiology
• Nutrition Science

Background:

• Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global health issue, often co-occurring with type 2 diabetes and dyslipidemia.
• Effective MASLD treatments are limited, but dietary interventions, particularly those involving fiber, show significant potential.
• Dietary fiber influences the gut microbiome, suggesting a role in managing MASLD.

Purpose of the Study:

• To investigate the impact of consuming fiber-enriched rolls on the gut microbiome and microbial metabolites in MASLD patients.
• To assess the effects of different fiber amounts (6g or 12g) on gut health indicators.

Main Methods:

• MASLD patients consumed fiber-enriched rolls (6g or 12g fiber).
• Anthropometric and laboratory parameters were measured at three timepoints.
• Fecal microbiome analysis was performed using 16S on nanopore sequencing.

Main Results:

• Firmicutes and Bacteroidetes were the dominant phyla.
• Short-chain fatty acid (SCFA) levels, specifically acetate and butyrate, changed significantly over time and with fiber intake.
• A high-fiber diet correlated with increased gut microbial phyla diversity (p = 0.006571).

Conclusions:

• Dietary fiber supplementation positively impacts gut microbiome composition and function in MASLD patients.
• Introducing appropriate amounts of fiber shows promise for improving gut microbiome-related aspects in MASLD management.
• Fiber-enriched foods may serve as a valuable dietary strategy for individuals with MASLD.