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Updated: Apr 28, 2026
Porous Silicon Microparticles for Delivery of siRNA Therapeutics
Published on: January 15, 2015
Surface Modification of Mesoporous Silica Nanoparticles for Application in Targeted Delivery Systems of Antitumour
Svetlana Kovtareva1, Lyazat Kusepova1, Gaukhar Tazhkenova1
1Department of Chemistry, Faculty of Natural Sciences, L.N. Gumilyov Eurasian National University, Astana 010000, Kazakhstan.
Abstract:
The problem of tumour therapy has attracted the attention of many researchers for many decades. One of the promising strategies for the development of new dosage forms to improve oncology treatment efficacy and minimise side effects is the development of nanoparticle-based targeted transport systems for anticancer drugs. Among inorganic nanoparticles, mesoporous silica deserves special attention due to its outstanding surface properties and drug-loading capability. This review analyses the various factors affecting the cytotoxicity, cellular uptake, and biocompatibility of mesoporous silica nanoparticles (MSNs), constituting a key aspect in the development of safe and effective drug delivery systems. Special attention is paid to technological approaches to chemically modifying MSNs to alter their surface properties. The stimuli that regulate drug release from nanoparticles are also discussed, contributing to the effective control of the delivery process in the body. The findings emphasise the importance of modifying MSNs with different surface functional groups, bio-recognisable molecules, and polymers for their potential use in anticancer drug delivery systems.
Insights
Mesoporous silica nanoparticles enhance anticancer drug delivery by improving efficacy and reducing side effects. Surface modifications and controlled release are key for safe and effective targeted cancer therapy.
Area of Science:
- Biomedical Engineering
- Materials Science
- Nanotechnology
Background:
- Tumor therapy requires improved efficacy and reduced side effects.
- Nanoparticle-based targeted drug delivery systems are a promising strategy.
- Mesoporous silica nanoparticles (MSNs) offer excellent surface properties and drug-loading capacity for oncology.
Purpose of the Study:
- To review factors influencing mesoporous silica nanoparticle (MSN) cytotoxicity, cellular uptake, and biocompatibility.
- To explore chemical modifications of MSNs for enhanced drug delivery.
- To discuss stimuli-responsive drug release mechanisms for controlled delivery.
Main Methods:
- Literature review of MSN properties and applications in drug delivery.
- Analysis of surface modification techniques for MSNs.
- Evaluation of factors affecting drug release kinetics.
Main Results:
- MSN properties like cytotoxicity, cellular uptake, and biocompatibility are crucial for drug delivery.
- Chemical modification of MSNs alters surface properties, impacting their performance.
- Stimuli-responsive drug release mechanisms enable controlled drug delivery.
Conclusions:
- Modifying MSNs with functional groups, biomolecules, and polymers is essential for effective anticancer drug delivery.
- Optimized MSNs show potential for safer and more effective cancer treatments.
- Further research into MSN surface engineering and controlled release is vital for clinical translation.
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