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Enhancing the Bioavailability of Resveratrol: Combine It, Derivatize It, or Encapsulate It?
Mohamed Salla1,2, Nadine Karaki1,3, Belal El Kaderi1
1Department of Biological and Chemical Sciences, School of Arts and Sciences, Lebanese International University, Khiyara-West Bekaa, Bayrut P.O. Box 146404, Lebanon.
Pharmaceutics
|April 27, 2024
Summary
Resveratrol shows therapeutic promise but suffers from poor bioavailability. This review explores strategies like combination therapy, derivatization, and nanoparticles to enhance resveratrol
Area of Science:
- Pharmacology
- Drug Delivery
- Medicinal Chemistry
Background:
- Resveratrol exhibits therapeutic potential but faces significant bioavailability and metabolic stability issues.
- These limitations hinder its clinical application, requiring high doses to achieve therapeutic effects.
Purpose of the Study:
- To review and compare strategies for modifying resveratrol to improve its biological and therapeutic efficacy.
- To provide a platform for directing future research on resveratrol-based treatments.
Main Methods:
- Discussion of combination therapies with established chemotherapeutic agents.
- Overview of resveratrol derivatization techniques (e.g., hydroxylation, glycosylation).
- Analysis of resveratrol encapsulation within various nanoparticle systems (polymers, metals, lipids).
Main Results:
- Combination therapies show synergistic effects against colon, liver, and gastric cancers.
- Resveratrol derivatization differentially impacts bioavailability and therapeutic outcomes.
- Nanoparticle encapsulation enhances resveratrol solubility, absorption, bioavailability, and efficacy.
Conclusions:
- Combination therapy, derivatization, and nanoparticle delivery are promising approaches to overcome resveratrol's limitations.
- These strategies hold potential for developing more effective resveratrol-based therapeutic options.
- Further research is warranted to optimize these methods for clinical translation.
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