Exploring Immersion Coating as a Cost-Effective Method for Small-Scale Production of Enteric-Coated Gelatin Capsules
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View abstract on PubMed
Summary
This summary is machine-generated.Immersion coating offers a cost-effective method for creating enteric-coated capsules on a small scale. Eudragit S100 provides superior process robustness for personalized medicine applications.
Area Of Science
- Pharmaceutical Technology
- Drug Delivery Systems
- Formulation Science
Background
- Coating solid dosage forms is crucial in pharmaceuticals but challenging for small-scale production.
- Personalized medicine and clinical settings require adaptable, small-scale coating solutions.
- Existing commercial enteric capsules may lack robustness depending on active pharmaceutical ingredients (APIs) and excipients.
Purpose Of The Study
- To evaluate immersion coating as a viable small-scale method for enteric-coated gelatin capsules.
- To compare the efficacy of different enteric coating polymers and concentrations.
- To assess the performance against commercially available enteric capsule shells.
Main Methods
- Utilized standard equipment for immersion coating of gelatin capsules.
- Tested two enteric coating polymers (including Eudragit S100) at various concentrations.
- Considered API solubility and compared results with commercial enteric capsules.
Main Results
- Successful enteric coating via immersion requires understanding API and polymer interactions.
- Commercial enteric capsules are not universally robust; performance depends on formulation.
- Eudragit S100 demonstrated superior process robustness and minimal development time.
Conclusions
- Immersion coating is a practical, cost-effective approach for small-scale enteric capsule production.
- Eudragit S100 is the preferred polymer for robust, low-development-time enteric coating.
- Formulation-specific considerations are essential for both coated and pre-made enteric capsules.
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