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Unveiling the Role of PAR 1: A Crucial Link with Inflammation in Diabetic Subjects with COVID-19
Ravinder Singh1, Varinder Singh1, Md Altamash Ahmad1
1Chitkara College of Pharmacy, Chitkara University, Rajpura 140401, Punjab, India.
Elevated serum PAR-1 levels indicate increased inflammation in COVID-19 patients with type 2 diabetes mellitus (T2DM). These findings suggest PAR-1 may be a key biomarker for inflammation in this patient group.
Area of Science:
- Biochemistry
- Immunology
- Endocrinology
Background:
- COVID-19 and type 2 diabetes mellitus (T2DM) share inflammatory pathways.
- Both conditions are linked to metabolic dysregulation and insulin resistance.
Purpose of the Study:
- To investigate differences in serum PAR-1 levels between COVID-19 patients with and without T2DM.
- To determine the correlation of PAR-1 levels with various biochemical and inflammatory markers.
Main Methods:
- Serum PAR-1 levels were measured using ELISA in 50 COVID-19 T2DM patients and 50 non-diabetic COVID-19 patients.
- Correlations were analyzed with HbA1c, BMI, CRP, IL-6, TNF-α, D-dimer, homocysteine, and NT-proBNP.
Main Results:
- COVID-19 T2DM patients exhibited significantly higher BMI and HbA1c levels.
- Increased serum PAR-1 concentrations and inflammatory biomarkers were observed in the T2DM group.
- Serum PAR-1 positively correlated with HbA1c, BMI, inflammatory cytokines, D-dimer, homocysteine, and NT-proBNP.
Conclusions:
- Elevated serum PAR-1 levels are associated with inflammation in COVID-19 patients with T2DM.
- Serum PAR-1 may serve as an independent biomarker for inflammation in this population.
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