A Green HPLC Approach to Florfenicol Analysis in Pig Urine
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View abstract on PubMed
Summary
This summary is machine-generated.Florfenicol (FF) antibiotic analysis in pig urine is now simpler and more sustainable. This new method aids in understanding FF excretion and environmental impact, promoting greener veterinary practices.
Area Of Science
- Veterinary Pharmacology
- Environmental Chemistry
- Analytical Chemistry
Background
- Florfenicol (FF) is a vital antibiotic for treating infections in domestic animals.
- Rapid urinary excretion of FF raises concerns about environmental contamination.
- Efficient analytical methods are needed to monitor FF in animal waste.
Purpose Of The Study
- To develop a sustainable chromatographic method for analyzing FF in pig urine.
- To investigate the urinary excretion profile of FF after intramuscular administration.
- To assess the environmental impact of FF analysis methods.
Main Methods
- Sample preparation involved centrifugation and filtration.
- Analysis was performed using a validated chromatographic method.
- Method validation included linearity, LOD, LOQ, repeatability, matrix effect, accuracy, and stability.
- Greenness of the method was evaluated using NEMI, GAPI, and AGREE metrics.
Main Results
- A simple, sustainable chromatographic method for FF in pig urine was established.
- The method demonstrated excellent validation parameters (LOD: 0.005 µg/mL, LOQ: 0.016 µg/mL, accuracy: 98-102%).
- Approximately 63% of the administered FF dose was excreted in pig urine within 48 hours.
- The developed method showed superior environmental performance compared to published techniques.
Conclusions
- The established chromatographic method provides a sustainable and efficient way to analyze FF in pig urine.
- Understanding FF's urinary excretion is crucial for managing environmental contamination.
- This greener analytical approach supports responsible antibiotic use in animal agriculture.
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