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Vesicular Drug Delivery Systems: Promising Approaches in Ocular Drug Delivery
Eslim Batur1,2,3, Samet Özdemir3, Meltem Ezgi Durgun3
1Health Science Institute, Istanbul University, 34126 Istanbul, Türkiye.
Pharmaceuticals (Basel, Switzerland)
|April 27, 2024
Summary
Vesicular drug delivery systems offer improved ocular bioavailability and retention compared to conventional methods. These advanced systems enhance drug efficacy for eye diseases while minimizing side effects.
Area of Science:
- Ophthalmology
- Pharmaceutics
- Nanotechnology
Background:
- The eye presents significant anatomical and physiological barriers to effective drug delivery.
- Conventional ocular dosage forms often suffer from poor bioavailability, short retention, and systemic side effects.
- Vesicular drug delivery systems have emerged as a promising alternative to overcome these limitations.
Purpose of the Study:
- To review various vesicular drug delivery systems for ocular applications.
- To highlight the advantages of vesicular systems over conventional ocular drug delivery methods.
- To discuss production techniques and therapeutic applications in managing ocular diseases.
Main Methods:
- Comprehensive literature review of vesicular drug delivery systems.
- Analysis of different vesicular formulations including liposomes, niosomes, ethosomes, and transfersomes.
- Examination of production methods and in-vitro/in-vivo studies on ocular drug delivery.
Main Results:
- Vesicular systems demonstrate enhanced ocular drug bioavailability and prolonged retention.
- These systems protect drugs from degradation and reduce systemic absorption.
- Targeted delivery and co-delivery of multiple drugs are achievable with vesicular formulations.
Conclusions:
- Vesicular drug delivery systems represent a significant advancement for treating ocular diseases.
- Their ability to improve drug properties and enable targeted delivery offers superior therapeutic potential.
- Further research into production and clinical application of these systems is warranted.
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