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Vaccination against Rabbit Hemorrhagic Disease Virus 2 (RHDV2) Using a Baculovirus Recombinant Vaccine Provides
Angela M Bosco-Lauth1, Amber Schueler2, Edward Midthun1
1Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Viruses
|April 27, 2024
Summary
Rabbit hemorrhagic disease virus 2 (RHDV2) vaccination provides lasting protection. Studies show vaccinated rabbits survived RHDV2 challenge 6 months after vaccination, unlike unvaccinated controls.
Area of Science:
- Veterinary Virology
- Immunology
- Rabbit Disease Research
Background:
- Rabbit hemorrhagic disease virus 2 (RHDV2) is a highly contagious and lethal virus that emerged in the US in 2018.
- RHDV2 poses a significant threat to both domestic and wild rabbit populations nationwide.
- Vaccination is considered the primary method for protecting rabbits against RHDV2.
Purpose of the Study:
- To evaluate the duration of immunity conferred by the Medgene Platform RHDV2 vaccine.
- To assess protection against RHDV2 challenge 6 months post-vaccination.
Main Methods:
- Rabbits were administered the Medgene RHDV2 vaccine or a placebo.
- Six months after vaccination, all rabbits were challenged with virulent RHDV2.
- Survival rates and clinical signs were monitored post-challenge.
Main Results:
- All rabbits that received the RHDV2 vaccine survived the challenge.
- 18 out of 19 unvaccinated control rabbits died within 10 days of challenge.
- Vaccination demonstrated significant protection against RHDV2 infection.
Conclusions:
- The Medgene RHDV2 vaccine provides lasting immunity for at least 6 months.
- Vaccination is a critical tool for managing RHDV2 in rabbit populations.
- Continued use of RHDV2 vaccination is recommended for rabbit owners.
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