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Experimental Study on SPR Array Sensing Chip Integrated with Microvalves.

Wanwan Chen1, Peng Wang1, Bin Li1,2

  • 1Department of Precision Instrument, Tsinghua University, Beijing 100084, China.

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|April 27, 2024
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Summary

This study presents a microfluidic system with integrated microvalves for surface plasmon resonance (SPR) sensing. The developed microvalves reliably control fluid flow, proving suitable for SPR array sensing applications.

Keywords:
SPR array detectionelectrolyte conductancemicrofluidic systempneumatic microvalve

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Area of Science:

  • Microfluidics
  • Biosensing
  • Surface Plasmon Resonance (SPR)

Background:

  • Microfluidic systems are crucial for precise fluid handling in biosensing.
  • Integrated microvalves offer enhanced control over sample and reagent delivery.
  • Surface Plasmon Resonance (SPR) is a label-free detection technique widely used in biochemical analysis.

Purpose of the Study:

  • To design and fabricate a novel microfluidic system with integrated microvalves for SPR sensing.
  • To characterize the performance and reliability of the microvalves.
  • To demonstrate the system's utility in SPR array sensing applications.

Main Methods:

  • Fabrication of a layered microfluidic chip using polydimethylsiloxane (PDMS) and polymethylmethacrylate (PMMA).
  • Integration of microvalves with electrodes for functional verification using a conductance method.
  • Testing microvalve closure pressure and duration-dependent operation.
  • Coordinated operation of multiple microvalves for sequential fluid flow control.
  • Integration with an SPR array sensing system for NaCl solution injection and detection.

Main Results:

  • Microvalves demonstrated full closure at a control pressure of 0.3 MPa.
  • Microvalve operation was found to be dependent on applied pressure duration.
  • Coordinated microvalve operation enabled sequential sample and reagent delivery.
  • The system successfully controlled NaCl solution injection in SPR detection experiments.
  • Phase change curves were observed in different chip regions, validating system performance.

Conclusions:

  • The developed microfluidic system with integrated microvalves is reliable and functional.
  • The microvalves are suitable for precise fluid control in SPR array sensing.
  • This technology offers potential for advanced microfluidic-based biosensing platforms.