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Updated: Jun 27, 2025

Author Spotlight: Insights into the Techniques and Findings of Recent Advancements in Epilepsy Research
Published on: October 13, 2023
CircRNA-associated ceRNA regulatory networks as emerging mechanisms governing the development and biophysiopathology
Maryam Kohansal1,2, Yasemin Khudiar Alghanimi3, Shaimaa R Banoon4
1Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.
Abstract:
The etiology of epilepsy is ascribed to the synchronized aberrant neuronal activity within the brain. Circular RNAs (circRNAs), a class of non-coding RNAs characterized by their circular structures and covalent linkage, exert a substantial influence on this phenomenon. CircRNAs possess stereotyped replication, transience, repetitiveness, and paroxysm. Additionally, MicroRNA (miRNA) plays a crucial role in the regulation of diverse pathological processes, including epilepsy. CircRNA is of particular significance due to its ability to function as a competing endogenous RNA, thereby sequestering or inhibiting miRNA activity through binding to target mRNA. Our review primarily concentrates on elucidating the pathological and functional roles, as well as the underlying mechanisms, of circRNA-miRNA-mRNA networks in epilepsy. Additionally, it explores the potential utility of these networks for early detection and therapeutic intervention.
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