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Stephanie Van Asbroeck1, Sebastian Köhler1, Martin P J van Boxtel1

  • 1Alzheimer Centrum Limburg, Department of Psychiatry and Neuropsychology, Mental Health and Neuroscience (MHeNs) Research Institute, Maastricht University, Maastricht, The Netherlands.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|April 27, 2024
PubMed

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Summary
This summary is machine-generated.

The LIfestyle for BRAin Health (LIBRA) index predicts dementia risk. This global study found lifestyle factors impact dementia risk across diverse populations, though regional and age differences exist.

Area of Science:

  • Gerontology
  • Epidemiology
  • Neuroscience

Context:

  • The LIfestyle for BRAin Health (LIBRA) index, a dementia risk score based on modifiable lifestyle factors, is validated in Western populations.
  • Global research is needed to assess the LIBRA index's applicability across diverse geographical and sociodemographic groups.

Purpose:

  • To investigate if the association between LIBRA scores and incident dementia is moderated by geographical location or sociodemographic characteristics.
  • To determine the global relevance of modifiable lifestyle factors in dementia risk.

Summary:

  • A global meta-analysis of 21 prospective cohorts (N=31,680) examined the association between LIBRA scores and dementia risk.
  • A one-standard-deviation increase in LIBRA score was linked to a 21% higher dementia risk.
Keywords:
agedementiadementia risk reductioneducationeffect modificationethnicityindividual participant data meta‐analysisinteractionlifestyleprimary preventionregionrisk factorrisk personalizationsexsocioeconomic

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  • The association was stronger in Asian versus European cohorts and in individuals ≤75 years old within the first 5 years of follow-up. No interactions were found with sex, education, or socioeconomic position.

    • Impact:

    • Modifiable risk and protective factors are relevant for dementia risk reduction across diverse geographical and sociodemographic groups.
    • Findings support the universal applicability of lifestyle interventions for dementia prevention.