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Updated: Jun 27, 2025
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Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
Published on: June 13, 2014
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Targeted Drug Nanodelivery and Immunotherapy for Combating Tumor Resistance
Yun Liu1, Xinyu Sun2, Chen Wei2
1School of Stomatology, Shandong Second Medical University, Weifang, 261053, China.
Combinatorial Chemistry & High Throughput Screening
|April 27, 2024
Summary
Chemotherapy resistance in tumors is a major challenge. This review details resistance mechanisms and highlights nanocarrier-based immunotherapy as a promising strategy to overcome drug resistance and improve cancer treatment outcomes.
Area of Science:
- Oncology
- Pharmacology
- Immunotherapy
Background:
- Chemotherapy resistance is a primary reason for treatment failure in cancer.
- Mechanisms include P-glycoprotein (P-gp) expression, tumor microenvironment (TME) alterations, platelet involvement, and cancer stem cells (CSCs).
Purpose of the Study:
- To review the molecular mechanisms of chemotherapy resistance.
- To summarize existing anti-resistance drugs and novel therapeutic strategies.
- To explore nanocarrier-based combination immunotherapy for overcoming drug resistance.
Main Methods:
- Literature review of chemotherapy resistance mechanisms.
- Analysis of current anti-resistance drugs.
- Examination of nanocarrier-based immunotherapy approaches.
Main Results:
- Identified key molecular drivers of chemotherapy resistance.
- Highlighted limitations of current anti-resistance therapies.
- Described the potential of nanocarriers combined with immunotherapy to target tumors and enhance immune response.
Conclusions:
- Nanocarrier-based combination immunotherapy offers a novel strategy to overcome tumor drug resistance.
- This approach enhances targeted drug delivery and modulates the immune system for improved efficacy.
- New strategies are suggested to improve tumor treatment and patient prognosis.
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