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Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
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Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

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Targeted Drug Nanodelivery and Immunotherapy for Combating Tumor Resistance

Yun Liu1, Xinyu Sun2, Chen Wei2

  • 1School of Stomatology, Shandong Second Medical University, Weifang, 261053, China.

Combinatorial Chemistry & High Throughput Screening
|April 27, 2024
PubMed

Insights

Chemotherapy resistance in tumors is a major challenge. This review details resistance mechanisms and highlights nanocarrier-based immunotherapy as a promising strategy to overcome drug resistance and improve cancer treatment outcomes.

Area of Science:

  • Oncology
  • Pharmacology
  • Immunotherapy

Background:

  • Chemotherapy resistance is a primary reason for treatment failure in cancer.
  • Mechanisms include P-glycoprotein (P-gp) expression, tumor microenvironment (TME) alterations, platelet involvement, and cancer stem cells (CSCs).

Purpose of the Study:

  • To review the molecular mechanisms of chemotherapy resistance.
  • To summarize existing anti-resistance drugs and novel therapeutic strategies.
  • To explore nanocarrier-based combination immunotherapy for overcoming drug resistance.

Main Methods:

  • Literature review of chemotherapy resistance mechanisms.
  • Analysis of current anti-resistance drugs.
  • Examination of nanocarrier-based immunotherapy approaches.

Main Results:

  • Identified key molecular drivers of chemotherapy resistance.
  • Highlighted limitations of current anti-resistance therapies.
  • Described the potential of nanocarriers combined with immunotherapy to target tumors and enhance immune response.

Conclusions:

  • Nanocarrier-based combination immunotherapy offers a novel strategy to overcome tumor drug resistance.
  • This approach enhances targeted drug delivery and modulates the immune system for improved efficacy.
  • New strategies are suggested to improve tumor treatment and patient prognosis.
Keywords:
Multidrug resistanceanti-resistance drugs.chemotherapyimmunotherapynanotherapytargeted drug delivery

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