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Overview of Exosomes

Overview of Exosomes

Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...

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Updated: May 2, 2026

An Innovative Method for Exosome Quantification and Size Measurement

An Innovative Method for Exosome Quantification and Size Measurement

Published on: January 17, 2015

Exosome Isolation and Detection: From Microfluidic Chips to Nanoplasmonic Biosensor.

Jianing Shen¹, Zhengtai Ma^2,3, Jiaqi Xu¹

¹School of Instrument Science and Optoelectronic Engineering, Beijing Information Science and Technology University, Beijing 100192, China.

ACS Applied Materials & Interfaces

|April 27, 2024

Summary

Exosomes are key cancer biomarkers. New microfluidic and nanoplasmonic biosensor technologies offer direct, sensitive detection for improved cancer diagnosis and prognosis.

Keywords:

detection exosome isolation microfluidic chip plasmonic biosensor

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An Innovative Method for Exosome Quantification and Size Measurement

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Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

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Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets

Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets

Published on: March 17, 2023

Area of Science:

Biomedical Engineering
Oncology
Nanotechnology

Background:

Exosomes are increasingly recognized as critical circulating biomarkers for cancer prognosis and diagnosis.
Exosomes play a vital role in cancer development and metastasis.
Current methods for exosome characterization are challenging and lack sensitivity.

Purpose of the Study:

To review novel strategies for exosome isolation and detection.
To analyze the advantages and limitations of emerging exosome detection technologies.
To guide researchers in developing improved exosome isolation and detection devices for clinical applications.

Main Methods:

Review of microfluidic chip-based technologies for exosome isolation and detection.
Analysis of nanoplasmonic biosensor applications for sensitive exosome detection.
Comparative assessment of different exosome detection methodologies.

Main Results:

Emerging technologies like microfluidic chips and nanoplasmonic biosensors offer direct, sensitive, and targeted exosome detection.
These advanced methods address limitations of existing exosome characterization techniques.
The reviewed technologies show promise for enhancing cancer diagnostics.

Conclusions:

Novel exosome detection technologies are crucial for advancing cancer diagnosis and prognosis.
Microfluidic chips and nanoplasmonic biosensors represent significant progress in exosome analysis.
Further development of these technologies can lead to improved clinical applications for cancer management.