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Related Concept Videos

Human Genetics01:28

Human Genetics

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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
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Related Experiment Video

Updated: Jun 27, 2025

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration
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[Genetic basis of postoperative cognitive dysfunction].

V A Saltanova1,2, O A Kicherova1, L I Reikhert1

  • 1Tyumen State Medical University, Tyumen, Russia.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|April 27, 2024
PubMed
Summary

Genetic markers like TOMM40 and APOE may influence postoperative cognitive dysfunction. This review details genes and mechanisms linked to anesthesia-induced cognitive impairment, summarizing evidence on genetic variants.

Keywords:
long-term anesthesiapostoperative cognitive dysfunction

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Area of Science:

  • Neuroscience
  • Genetics
  • Anesthesiology

Background:

  • Postoperative cognitive dysfunction (POCD) is a significant concern following anesthesia and surgery.
  • The precise etiology of POCD remains incompletely understood, with genetic predisposition being a key area of investigation.

Purpose of the Study:

  • To review and synthesize existing literature on genetic markers associated with the development of POCD.
  • To elucidate the pathogenetic mechanisms linking specific genes to cognitive impairment after anesthesia.

Main Methods:

  • Systematic literature review of studies investigating genetic variants and POCD.
  • Analysis of reported pathogenetic pathways involving identified genes.

Main Results:

  • Several genes, including TOMM40, APOE, TREM2, METTL3, PGC1a, HMGB1, and ERMN, are highlighted as potential contributors to POCD.
  • Evidence suggests that variations in these genes influence the risk and development of cognitive dysfunction post-surgery.

Conclusions:

  • Genetic factors play a crucial role in the susceptibility to and manifestation of POCD.
  • Further research into these genetic markers and their mechanisms can inform targeted prevention and treatment strategies for POCD.