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Related Experiment Videos

Positive feedback sympathetic reflexes and hypertension.

A Malliani, M Pagani, M Bergamaschi

    The American Journal of Cardiology
    |October 22, 1979
    PubMed
    Summary

    Aortic distension in dogs triggers a pressor reflex, increasing blood pressure via spinal cord pathways. This sympathetic nervous system activation can override other blood pressure regulation systems.

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    Area of Science:

    • Cardiovascular Physiology
    • Neuroscience

    Background:

    • The thoracic aorta contains sensory receptors involved in blood pressure regulation.
    • Sympathetic nervous system plays a crucial role in maintaining arterial pressure.

    Purpose of the Study:

    • To describe a pressor reflex originating from the thoracic aorta in conscious dogs.
    • To investigate the neural pathways and cardiovascular effects of this reflex.

    Main Methods:

    • Eliciting a pressor reflex through thoracic aorta distension in conscious dogs.
    • Monitoring arterial blood pressure and sympathetic outflow.
    • Investigating the role of the spinal cord as the reflex center.

    Main Results:

    • Thoracic aorta distension activates sympathetic afferent fibers.
    • This activation leads to increased arterial blood pressure.
    • The spinal cord serves as the central processing site for this positive feedback reflex.

    Conclusions:

    • A pressor reflex from the thoracic aorta exists in conscious dogs.
    • This reflex increases arterial blood pressure by enhancing sympathetic activity.
    • The spinal cord mediates this reflex, influencing cardiovascular homeostasis.

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