Trends in the prevalence and incidence of Crohn's disease in Japan and the United States
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View abstract on PubMed
Summary
This summary is machine-generated.Crohn's disease (CD) affects younger males more in Japan than the US, with higher prevalence and incidence in the US. Understanding these epidemiological differences is key for targeted prevention strategies.
Area Of Science
- Gastroenterology
- Epidemiology
- Public Health
Background
- Crohn's disease (CD) is a chronic inflammatory bowel disease with a significant global health burden.
- Epidemiological data on CD prevalence and incidence can vary significantly by geographic region and demographic factors.
Purpose Of The Study
- To describe patient demographic characteristics of Crohn's disease (CD) in Japan and the United States (US).
- To estimate and compare the annual prevalence and incidence rates of CD between Japan and the US from 2010 to 2019.
Main Methods
- Utilized large employment-based healthcare claims databases: Japan Medical Data Center (JMDC) and Merative MarketScan (Merative).
- Identified CD patients using diagnostic and treatment codes, confirming cases algorithmically.
- Standardized prevalence and incidence rates for sex and age using the Merative US population data.
Main Results
- CD patients were diagnosed at a younger age in Japan (mean 33.6 years) compared to the US (39.4 years), with a higher proportion of males in Japan (71.5%) versus the US (45.1%).
- Annual CD prevalence per 100,000 population significantly increased in both countries, rising from 34.2 to 54.5 in Japan and 163.3 to 224.2 in the US by 2019.
- The US exhibited a nearly fourfold higher annual incidence rate of CD (21.0 per 100,000 person-years) compared to Japan (5.5 per 100,000 person-years) in 2019, with rates remaining stable over time in both countries.
Conclusions
- Significant differences in Crohn's disease epidemiology exist between Japan and the US.
- Further research into the underlying causes of these epidemiological disparities is warranted.
- Understanding these differences can aid in identifying at-risk populations and developing targeted preventive measures for CD in each country.
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