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Related Experiment Videos

Cardiac receptors: normal and disturbed function.

D E Donald, J T Shepherd

    The American Journal of Cardiology
    |October 22, 1979
    PubMed
    Summary
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    Cardiac mechanoreceptors tonically inhibit the vasomotor center, influencing blood pressure and renal function. Their activity increases during conditions like coronary occlusion, affecting cardiovascular regulation.

    Area of Science:

    • Cardiovascular Physiology
    • Autonomic Nervous System Regulation

    Background:

    • The heart contains a network of fibers connected to the medullary cardiovascular centers via vagal afferent fibers.
    • Arterial baroreceptors play a role in regulating blood pressure.

    Purpose of the Study:

    • To elucidate the role of cardiac mechanoreceptors in cardiovascular control.
    • To understand how cardiac mechanoreceptors influence blood pressure, renal function, and vascular beds.

    Main Methods:

    • Interruption of vagal afferent fiber traffic using vagal cooling.
    • Prevention of input from arterial baroreceptors.
    • Observation of arterial blood pressure changes.

    Main Results:

    • Interruption of vagal afferent fibers and prevention of baroreceptor input led to increased arterial blood pressure, indicating tonic inhibition of the vasomotor center by cardiac receptors.

    Related Experiment Videos

  • Cardiac mechanoreceptors in the atria and ventricles respond to changes in pressure, contractility, and volume.
  • Cardiac mechanoreceptors significantly influence the renal bed, with effects enhanced by hypercapnia and greater in humans than arterial mechanoreceptors for muscle vessels.
  • Cardiac mechanoreceptors are more sensitive to blood volume changes than arterial mechanoreceptors and modulate renin output.
  • Discharge rate of cardiac receptors increases during coronary occlusion.

    • Conclusions:

    • Cardiac mechanoreceptors exert tonic inhibitory control over the vasomotor center.
    • Cardiac mechanoreceptors play a crucial role in regulating blood pressure, renal function, and vascular tone, with distinct roles in different vascular beds and species.
    • Cardiac mechanoreceptor sensitivity to blood volume and their response to pathological conditions like coronary occlusion highlight their importance in cardiovascular homeostasis.