Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Cyclin A2 induces cytokinesis in human adult cardiomyocytes and drives reprogramming in mice.

NPJ Regenerative medicine·2025

Same author

Cyclin A2 Induces Human Adult Cardiomyocyte Cytokinesis and Elicits Cardiomyocyte Reprogramming and Dedifferentiation.

Research square·2025

Same author

Cyclin A2 Induces Cytokinesis in Human Adult Cardiomyocyte and Drives Reprogramming in Mice.

bioRxiv : the preprint server for biology·2024

Same author

Ablating Myocardium Using Nanosecond Pulsed Electric Fields: Preclinical Assessment of Feasibility, Safety, and Durability.

Circulation. Arrhythmia and electrophysiology·2024

Same author

Ultrastructural insights from myocardial ablation lesions from microsecond pulsed field vs radiofrequency energy.

Heart rhythm·2023

Same author

A new strategy for cardiac protection.

eLife·2023

Search research articles

Related Experiment Video

Updated: Jun 27, 2025

A Modified Simple Method for Induction of Myocardial Infarction in Mice

A Modified Simple Method for Induction of Myocardial Infarction in Mice

Published on: December 3, 2021

Pop-Out Myocardial Infarction Induction in Mice.

Bingyan J Wang¹, Hina W Chaudhry²

¹Icahn School of Medicine at Mount Sinai, Department of Cardiology, New York, NY, USA.

Methods in Molecular Biology (Clifton, N.J.)

|April 27, 2024

Summary

Researchers developed a fast and reliable method to induce consistent myocardial infarction (MI) size in mice. This technique is crucial for reproducible preclinical studies of cardiac repair and cardiovascular ischemic disease.

Keywords:

Ischemia LAD Myocardial infarction

More Related Videos

Induction of Myocardial Infarction and Myocardial Ischemia-Reperfusion Injury in Mice

Induction of Myocardial Infarction and Myocardial Ischemia-Reperfusion Injury in Mice

Published on: January 19, 2022

Murine Myocardial Infarction Model using Permanent Ligation of Left Anterior Descending Coronary Artery

Murine Myocardial Infarction Model using Permanent Ligation of Left Anterior Descending Coronary Artery

Published on: August 16, 2019

Related Experiment Videos

Last Updated: Jun 27, 2025

A Modified Simple Method for Induction of Myocardial Infarction in Mice

A Modified Simple Method for Induction of Myocardial Infarction in Mice

Published on: December 3, 2021

Induction of Myocardial Infarction and Myocardial Ischemia-Reperfusion Injury in Mice

Induction of Myocardial Infarction and Myocardial Ischemia-Reperfusion Injury in Mice

Published on: January 19, 2022

Murine Myocardial Infarction Model using Permanent Ligation of Left Anterior Descending Coronary Artery

Murine Myocardial Infarction Model using Permanent Ligation of Left Anterior Descending Coronary Artery

Published on: August 16, 2019

Area of Science:

Cardiovascular Research
Preclinical Animal Models
Surgical Techniques

Background:

Myocardial infarction (MI) in mice is a key model for studying human cardiovascular ischemic disease.
Reproducible infarct size is essential for accurate quantitative analysis in cardiac repair research.

Purpose of the Study:

To present a novel, rapid, and dependable method for inducing consistent infarct size in mouse models.
To improve the reliability of preclinical cardiac repair studies.

Main Methods:

A novel surgical technique for MI induction in mice.
Focus on achieving consistent infarct size within a short procedure time (<1 minute).

Main Results:

The described method reliably induces a consistent infarct size in mice.
The procedure is quick, taking less than a minute to complete.

Conclusions:

This method offers a significant improvement for preclinical cardiac repair studies requiring reproducible MI models.
The technique enhances the quantitative and analytical capabilities in cardiovascular research.