Prognostic value of large amino acid transporter type 1 (LAT1) expression in pulmonary adenocarcinoma: A tissue...

Area of Science:

• Oncology
• Molecular Biology
• Cancer Research

Background:

• Large amino acid transporter type 1 (LAT1) is crucial for cancer cell growth and survival.
• LAT1 expression may serve as a prognostic marker in various cancers.
• Targeting LAT1 presents a potential therapeutic strategy in oncology.

Purpose of the Study:

• To investigate the prognostic significance of LAT1 expression in lung cancer.
• To specifically analyze LAT1 expression in different subtypes of lung adenocarcinoma.
• To determine if LAT1 can aid in stratifying patients with adenocarcinoma based on prognosis.

Main Methods:

• Analysis of 717 surgically resected lung adenocarcinoma specimens using immunohistochemistry.
• Evaluation of LAT1 expression levels and correlation with tumor subtypes.
• Statistical analysis to determine the prognostic value of LAT1 expression.

Main Results:

• LAT1 expression was observed in 27.1% of lung adenocarcinoma cases.
• Higher LAT1 expression correlated with increased architectural grade in adenocarcinoma subtypes.
• Patients with papillary adenocarcinoma and high LAT1 expression showed significantly lower overall survival (10-year survival: 45.6% vs. 60.8%, p < 0.001).

Conclusions:

• LAT1 expression is elevated in high-grade pulmonary adenocarcinoma subtypes.
• LAT1 expression is a valuable predictor of prognosis in lung adenocarcinoma.
• LAT1 facilitates prognostic stratification, particularly in papillary adenocarcinoma.