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Updated: Jul 25, 2026
08:51
A New Murine Model of Endovascular Aortic Aneurysm Repair
Published on: July 7, 2013
14.4K
Editor's Choice - A Core Outcome Set for Intact Abdominal Aortic Aneurysm Repair.
Matthew Machin1, Anders Wanhainen2, Mario D'Oria3
1Department of Surgery and Cancer, Imperial College London, London, UK.
Summary
A core outcome set was developed for abdominal aortic aneurysm (AAA) repair, including death, rupture, quality of life, and cognitive function. This framework ensures consistent reporting in AAA studies for better clinical effectiveness assessment.
Area of Science:
- Vascular Surgery
- Health Outcomes Research
- Patient-Centered Care
Background:
- Advances in abdominal aortic aneurysm (AAA) management necessitate robust assessment of clinical effectiveness.
- Core Outcome Sets (COS) improve evidence synthesis and stakeholder representation in clinical research.
- International consensus is needed for standardized outcomes in AAA repair.
Purpose of the Study:
- To develop an international core outcome set for intact abdominal aortic aneurysm (AAA) repair.
- To establish a minimum framework for outcome measurement in AAA studies.
- To incorporate patient and stakeholder perspectives in defining essential research outcomes.
Main Methods:
- Systematic review of published outcomes and focus groups with patients, carers, and nurses.
- A 38-item Delphi consensus survey in lay language, translated into local languages.
- Multistakeholder consensus meeting following two rounds of Delphi survey with international participants.
Main Results:
- Six core outcomes were unanimously endorsed after Delphi survey rounds and consensus meeting.
- Endorsed outcomes include: 30-day mortality, secondary AAA rupture, quality of life, cognitive functioning, 5-year survival, and continued sac growth.
- The process involved 98 respondents in round 1 and 90 in round 2 of the Delphi survey.
Conclusions:
- Six core outcomes are recommended as a minimum framework for all future studies and registries of intact AAA repair (open and endovascular).
- Further research is required to select validated instruments for quality of life and cognitive functioning assessment.
- Standardized outcome reporting will enhance comparability and interpretation of AAA repair research.
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