Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

31.0K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
31.0K
Human Genetics01:28

Human Genetics

564
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
564
Neurochemical Transmission: Sites of Drug Action01:26

Neurochemical Transmission: Sites of Drug Action

2.3K
Neurochemical transmission, the conduction of electrical impulses between neurons mediated by neurotransmitters, plays a vital role in various physiological processes. Autonomic drugs exert their effects by modulating neurotransmission within the autonomic nervous system. For instance, drugs such as hemicholinium block the precursor uptake necessary for synthesizing acetylcholine, an essential autonomic neurotransmitter. Following synthesis, neurotransmitters are stored in vesicles. Metyrosine...
2.3K
CNS Stimulants: Cocaine, Amphetamines and Cannabinoids01:24

CNS Stimulants: Cocaine, Amphetamines and Cannabinoids

187
CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its...
187
Epistasis Analysis01:09

Epistasis Analysis

5.0K
Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...
5.0K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

6.3K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cost-Effectiveness of Vaccine for the Prevention of Herpes Zoster in Kidney Transplant Recipients in Thailand.

Value in health regional issues·2026
Same author

Phenanthrenoids and oxoaporphine alkaloids from <i>Monoon fuscum</i> B. Xue & R.M.K. Saunders and their biological activities.

Natural product research·2026
Same author

How Many Veteran COVID-19 Cases Were There during the Pandemic?

Journal of medical virology·2026
Same author

Orthogonally self-sorted hydrogels with pathway-dependent morphology guide bimetallic nanozyme formation.

Chemical communications (Cambridge, England)·2026
Same author

Comparing the association between out-of-pocket cost burden and cost-related care avoidance among individuals with and without a history of cancer.

Cancer·2026
Same author

Estimating the distributional impact of improving access to snake antivenom in urban and rural Lao People's Democratic Republic: An extended cost-effectiveness analysis.

PLoS neglected tropical diseases·2026

Related Experiment Video

Updated: Jun 27, 2025

Author Spotlight: Enhancements in Gene Expression Regulation Research
07:10

Author Spotlight: Enhancements in Gene Expression Regulation Research

Published on: September 15, 2023

1.7K

Phytocannabinoids in neuromodulation: From omics to epigenetics.

Subhadip Banerjee1, Debolina Saha2, Rohit Sharma3

  • 1Medicinal Plant Innovation Center of Mae Fah Luang University, Mae Fah Luang University, ChiangRai, 57100, Thailand.

Journal of Ethnopharmacology
|April 27, 2024
PubMed
Summary
This summary is machine-generated.

Phytocannabinoids show potential as neuromodulators for neurological disorders, with effects varying by individual factors. Strategic, personalized use is key to harnessing their benefits while mitigating risks associated with cannabis compounds.

Keywords:
CannabidomicsEpigeneticsNeurodegenerative disorderNeuromodulationPhytocannabinoidsTranscriptomic

More Related Videos

Lipidomics and Transcriptomics in Neurological Diseases
09:58

Lipidomics and Transcriptomics in Neurological Diseases

Published on: March 18, 2022

3.5K
Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
14:56

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

4.5K

Related Experiment Videos

Last Updated: Jun 27, 2025

Author Spotlight: Enhancements in Gene Expression Regulation Research
07:10

Author Spotlight: Enhancements in Gene Expression Regulation Research

Published on: September 15, 2023

1.7K
Lipidomics and Transcriptomics in Neurological Diseases
09:58

Lipidomics and Transcriptomics in Neurological Diseases

Published on: March 18, 2022

3.5K
Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
14:56

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

4.5K

Area of Science:

  • Neuroscience
  • Pharmacology
  • Genetics

Background:

  • Recent advances in metabolomics, transcriptomics, and epigenetics offer new insights into phytocannabinoids' pharmacological roles.
  • Phytocannabinoids are being explored for their potential as neuromodulators in treating various neurological and psychiatric conditions, including anxiety, depression, epilepsy, Alzheimer's, Parkinson's disease, and autism.

Purpose of the Study:

  • To review the neurobiological roles of cannabis extracts and key phytocannabinoids.
  • To focus on metabolomics, transcriptomics, epigenetics, and mechanisms of action in various models and clinical trials.
  • To understand the effects of phytocannabinoids on neuromodulation using bioinformatics and network pharmacology.

Main Methods:

  • Extensive literature search across major scientific databases (Google Scholar, Scopus, Web of Science, PubMed).
  • Utilized bioinformatics, network pharmacology, and enrichment analysis to investigate phytocannabinoid effects.
  • Focused on data from cell lines, animal models, and human clinical trials.

Main Results:

  • Cannabidomics reveals metabolite variability influencing medicinal/abusive potential, crucial for quality control.
  • Phytocannabinoids interact with cannabinoid and non-cannabinoid receptors, showing promise for neurodegenerative diseases.
  • Network analysis identified key pathways (e.g., Rap1, dopaminergic synapse, ErbB, PI3K-Akt) involved in phytocannabinoid action, highlighting neuro-inflammation amelioration and personalized medicine potential.

Conclusions:

  • Phytocannabinoids exhibit significant neuromodulatory effects, offering promise for personalized neuropsychiatric treatments.
  • Strategic utilization is essential to maximize therapeutic benefits and avoid adverse effects.
  • Further research into neuro-epigenetics and systems pharmacology of phytocannabinoid combinations is recommended.