The Prognostic Immune and Nutritional Indices Are Independent Prognostic Factors for Esophageal Cancer Patients Who Receive Curative Treatment
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View abstract on PubMed
Summary
This summary is machine-generated.The prognostic immune and nutritional index (PINI) is a valuable tool for predicting outcomes in esophageal cancer patients. Higher PINI scores indicate better survival rates and reduced recurrence risk after curative treatment.
Area Of Science
- Oncology
- Immunonutrition
- Prognostic Biomarkers
Background
- The prognostic immune and nutritional index (PINI) has emerged as a significant marker for assessing prognosis.
- Its utility in esophageal cancer patients undergoing curative treatment requires further investigation.
Purpose Of The Study
- To evaluate the clinical impact of the PINI in esophageal cancer patients.
- To determine if PINI can serve as an independent prognostic factor for survival and recurrence.
Main Methods
- Retrospective analysis of 180 esophageal cancer patients who received curative resection.
- Calculation of PINI based on pre-operative serum albumin and monocyte concentrations.
Main Results
- Patients with a PINI below 3.0 (PINI-low) had significantly lower 3- and 5-year overall survival rates (45.2% and 33.5%) compared to those with a PINI above 3.0 (PINI-high) (69.1% and 61.8%).
- PINI was identified as an independent prognostic factor for overall survival (HR=2.091, p=0.003) and recurrence-free survival.
- The PINI-low group exhibited a higher incidence of hematological recurrence (46.8%) than the PINI-high group (21.1%).
Conclusions
- The PINI demonstrates potential as a prognostic marker for esophageal cancer.
- It may aid in the treatment and management strategies for patients with esophageal cancer.
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