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Related Experiment Videos

Silicon metabolism: the basic facts in renal failure.

G Berlyne, E Dudek, A J Adler

    Kidney International. Supplement
    |December 1, 1985
    PubMed
    Summary

    Silicon accumulates in the body during hemodialysis, with levels significantly elevated in patients with chronic renal failure. Hemodialysis patients sequester approximately 58 grams of silicic acid annually.

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    Area of Science:

    • Nephrology
    • Biochemistry
    • Materials Science

    Background:

    • Elevated silicon levels are observed in patients with chronic renal failure.
    • Hemodialysis patients exhibit significantly higher plasma silicon levels compared to control subjects.

    Purpose of the Study:

    • To investigate silicon levels in plasma and urine of normal subjects, chronic renal failure patients, and hemodialysis patients.
    • To understand silicon dynamics and excretion during hemodialysis.

    Main Methods:

    • Analysis of plasma and urine silicon levels in different patient groups.
    • Correlation analysis of urinary silicon excretion with creatinine clearance and other urinary parameters.
    • Assessment of silicon transfer from dialysate to blood during hemodialysis.

    Main Results:

    • Plasma silicon levels were elevated in chronic renal failure and threefold higher in hemodialysis patients.
    • Urinary silicon excretion correlated with creatinine clearance, urinary osmolality, magnesium, and calcium.
    • Commercial dialysate contains high silicon concentrations, leading to blood transfer via a concentration gradient.

    Conclusions:

    • Silicon is rapidly sequestered in the body during hemodialysis.
    • Hemodialysis alone contributes to an estimated annual silicic acid sequestration of 58 grams.

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