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Updated: Jun 27, 2025

X-Ray Crystallography to Study the Oligomeric State Transition of the Thermotoga maritima M42 Aminopeptidase TmPep1050
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Published on: May 13, 2020

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Cyclodipeptide oxidase is an enzyme filament

Michael P Andreas1, Tobias W Giessen2

  • 1Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.

Nature Communications
|April 27, 2024
PubMed
Summary

Researchers characterized the Streptomyces noursei enzyme AlbAB, a cyclodipeptide oxidase (CDO). This megadalton enzyme filament is crucial for albonoursin antibiotic biosynthesis and its activity depends on filament formation.

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