Association of the TRIM family protein with survival outcomes and clinicopathological features in colorectal cancer:...

Area of Science:

• Oncology
• Molecular Biology
• Genetics

Background:

• Tripartite Motif (TRIM) proteins are implicated in various cancers.
• The prognostic value of TRIM proteins in colorectal cancer (CRC) is debated.
• This study clarifies the association between TRIM proteins and CRC patient outcomes.

Purpose of the Study:

• To determine if TRIM proteins serve as prognostic factors in colorectal cancer (CRC).
• To evaluate the relationship between TRIM protein expression and clinicopathological features in CRC patients.

Main Methods:

• A meta-analysis was conducted on studies from multiple databases (PubMed, Embase, Web of Science, CNKI, Weipu).
• Eligible studies evaluated TRIM proteins' association with overall survival (OS) and clinicopathological features in CRC.
• Fixed-effects models were used to pool hazard ratios (HR) and odds ratios (OR) with 95% confidence intervals (CI).

Main Results:

• Twelve studies including 1608 patients were analyzed.
• Elevated TRIM proteins significantly correlated with shorter OS (HR=2.42) and worse recurrence-free survival (RFS) (HR=2.51).
• TRIM overexpression was linked to advanced TNM stage, deep invasion, lymph node metastasis, and perineural invasion.

Conclusions:

• TRIM proteins are significant predictors of tumor progression and poor prognosis in CRC.
• TRIM proteins represent potential therapeutic targets for colorectal cancer treatment.