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[Pilocytic astrocytoma with KRAS gene mutation: a clinicopathological analysis of two cases]

T P Yu1, M X Zhang1, J Y Zhang1

  • 1Department of Pathology, West China Hospital, Sichuan University, Chengdu 610041, China.

Zhonghua Bing Li Xue Za Zhi = Chinese Journal of Pathology
|April 28, 2024
PubMed
Abstract

No abstract available in PubMed .

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The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
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