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Updated: Jun 27, 2025

Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum
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Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum

Published on: May 3, 2024

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Mechanistic role of pyroptosis in tumor microenvironment and tumor immunotherapy

Rukset Attar1, Muhammad Zahid Qureshi2, Uteuliyev Yerzhan Sabitaliyevich3

  • 1Department of Obstetrics and Gynecology, Yeditepe University Hospital, 34755 Istanbul, Turkey. ruksetattar@hotmail.com.

Cellular and Molecular Biology (Noisy-Le-Grand, France)
|April 28, 2024
PubMed

Insights

Pyroptosis, a programmed cell death pathway, involves gasdermin pore formation and plays a key role in immunity and cancer. Understanding its signaling pathways can help target cancer inhibition and metastasis.

Area of Science:

  • Cell Biology
  • Immunology
  • Oncology

Background:

  • Programmed cell death (PCD) pathways are crucial for development and disease.
  • Pyroptosis is a pro-inflammatory cell death form regulated by gasdermin pore formation.
  • Pyroptosis is critical in innate immunity and influenced by inflammasome-dependent and independent cascades.

Purpose of the Study:

  • To review the regulation of pyroptosis by signaling pathways.
  • To analyze pyroptosis's role in cancer inhibition and metastasis.

Main Methods:

  • Comprehensive literature review of signaling pathways regulating pyroptosis.
  • Analysis of pyroptosis mechanisms in cancer biology.

Main Results:

  • Pyroptosis, characterized by gasdermin-NT pore formation, is a key inflammatory cell death.
  • Signaling pathways intricately regulate pyroptosis in the context of cancer.
  • Pyroptosis influences cancer inhibition and the metastatic spread of cancer cells.

Conclusions:

  • Understanding the interplay between signaling pathways and pyroptosis is vital.
  • This knowledge can optimize therapeutic strategies targeting cancer progression.
  • Further research into pyroptosis mechanisms holds promise for cancer treatment.

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