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Ventilatory pattern following diazepam and lorazepam.

I O Adeoshun, T E Healy, J M Patrick

    Anaesthesia
    |May 1, 1979
    PubMed
    Summary
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    Intravenous lorazepam (2 mg) significantly altered breathing patterns in patients undergoing surgery, causing periodic ventilation in most. Diazepam (10 mg) did not produce this effect.

    Area of Science:

    • Anesthesiology
    • Pharmacology
    • Respiratory Physiology

    Background:

    • Benzodiazepines are commonly used for sedation in surgical patients.
    • Understanding their effects on respiratory function is crucial for patient safety.

    Purpose of the Study:

    • To investigate the impact of intravenous diazepam and lorazepam on ventilatory patterns.
    • To compare the respiratory effects of equipotent doses of these two benzodiazepines.

    Main Methods:

    • Two groups of ten patients each were studied prior to elective surgery.
    • Patients received either intravenous diazepam (10 mg) or lorazepam (2 mg).
    • Ventilatory patterns were monitored post-injection.

    Main Results:

    Related Experiment Videos

  • Nine out of ten patients who received intravenous lorazepam (2 mg) exhibited a periodic pattern of ventilation.
  • The ventilatory pattern following intravenous diazepam (10 mg) was not specified as periodic.

    • Conclusions:

    • Intravenous lorazepam, at a dose of 2 mg, can induce periodic breathing in surgical patients.
    • Further research is needed to fully elucidate the respiratory depressant effects of lorazepam compared to diazepam.