[Early cortical atrophy in REM sleep behavior disorder]
María José Abenza Abildua1, Elvira Lanz Santos2, Luis Moreno Domínguez2
1Unidad del Sueño, Sección de Neurología, Hospital Universitario Infanta Sofía. Fundación para la Investigación e Innovación Biomédica del Hospital Universitario Infanta Sofía y Hospital Universitario del Henares, Madrid, España.
Medicina Clinica
|April 28, 2024
Summary
Cortical atrophy on brain imaging can predict neurodegenerative disease in patients with REM sleep behavior disorder (RSBD). Absence of atrophy suggests slower disease progression, warranting further research.
Area of Science:
- Neurology
- Radiology
- Sleep Medicine
Background:
- REM sleep behavior disorder (RSBD) may precede neurodegenerative disease.
- Identifying early markers for neurodegeneration in RSBD is crucial.
Purpose of the Study:
- To evaluate cranial CT and MRI as early predictors of cortical atrophy in RSBD patients.
- To assess the utility of imaging in identifying early neurodegenerative disease.
Main Methods:
- Retrospective analysis of 54 RSBD patients (2012-2022).
- Review of cranial CT and MRI scans by a neuroradiologist.
- Assessment for cortical atrophy using scales like GCA.
Main Results:
- 10 out of 54 patients (18.5%) showed atrophy greater than expected for age.
- All 10 patients with significant atrophy were diagnosed with neurodegenerative disease.
- Patients without atrophy at diagnosis showed slower progression over 10 years.
Conclusions:
- Cortical atrophy on imaging may predict early neurodegeneration in RSBD.
- Absence of atrophy might indicate a slower disease course.
- Larger studies are needed to confirm these findings.
Keywords:
Atrofia corticalCognitive impairmentCortical atrophyCortical gray matterCranial resonanceDemenciaDementiaDeterioro cognitivoREM sleep behavior disorderResonancia cranealSustancia gris corticalTrastorno de conducta REMMore Related Videos
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